Premier League wrap: Sheffield United relegated after heavy defeat to Alexander Isak-inspired Newcastle

Alexander Isak took his tally for the season to 23 as Newcastle recovered from a dreadful start to end Sheffield United's stay in the Premier League with a 5-1 victory.

The Blades took a deserved fifth-minute lead through Anel Ahmedhodzic to silence a crowd of 52,196 at St James' Park as the Magpies turned in a dismal first-half performance, yet still went in level at the break courtesy of Isak's sweet strike.

They scored four times inside 18 second-half minutes through Bruno Guimaraes, Isak, Ben Osborn's own goal and substitute Callum Wilson to secure a 5-1 win which relegated the visitors and took their total against them in two games this season to a Premier League record 13 goals following September's 8-0 victory at Bramall Lane.

Luton's bid took another hit as Rob Edwards' men were beaten 2-1 at his old club Wolves.

A week on from the 5-1 hammering at the hands of Brentford at Kenilworth Road, the Hatters fell behind through Hwang Hee-chan's finish just before the interval and a diving header from Toti then doubled the hosts' advantage five minutes into the second half.

Carlton Morris pulled a goal back with 10 minutes of normal time to go but Luton were unable to save themselves from a third successive loss and fifth in six games.

Victorious only once in their last 14 league outings, they remain a point adrift of safety in 18th with three games remaining, one fewer than 17th-placed Nottingham Forest, who host Manchester City on Sunday.

Gary O'Neil's Wolves move up to 10th having ended their six-match winless run in the league.

Jeffrey Schlupp scored an 87th-minute wondergoal as Crystal Palace rescued a late 1-1 draw with Fulham at Craven Cottage.

Marco Silva's men took a while to get going but they took the lead through